SYNVISC ONE® is an injectable fluid that is non-pyrogenic, sterile, and elastoviscous. SYNVISC ONE® contains hylans, derived from hyraluronan, the substance that provides elastoviscosity to synovial fluid. SYNVISC ONE® can temporarily replace or supplement the synovial fluid of the joint before the hylans break down within the body, producing only nontoxic byproducts. Although SYNVISC ONE® benefits patients in all stages of osteoarthritis joint problems, it is most effective in active patients who regularly use the affected joint. SYNVISC ONE® works through viscosupplementation, restoring volume and viscosity to the tissues of the arthritic joint to decrease joint pain and discomfort and allow greater movement. Only physicians should use or supervise SYNVISC ONE® injections, with an initial 6 ml injection of SYNVISC ONE® into the knee followed by another injection after six months if needed. Data shows patients can benefit from a single SYNVISC ONE® injection for up to twenty-six weeks.