RADIESSE™ 1.5cc This injectable sub-dermal implant is a cohesive, semi-solid gel with calcium hydroxylapatite particles that is latex-free, non-pyrogenic, and steam sterilized. RADIESSE™ 1.5cc comes in a syringe with a standard luer fitting, inside a foil pouch and box that is easy to store. For plastic and reconstructive surgery to restore or augment soft tissue in the facial area, inject RADIESSE™ into the deep dermis or sub-dermis, although the depth of injection and amount varies depending on the location and how much augmentation is needed. Be sure to inject RADIESSE™ deep enough to avoid nodules forming near the skin's surface or ischemia of the overylying tissue. While the calcium hydroxylapatite remains at the injection site, the RADIESSE™ gel gradually dissipates to be replaced by soft tissue, providing long-term but not permanent restoration. As a Class III Medical Device, determined by Annex IV of the MDD, only medical personnel authorized by local regulations should administer RADIESSE™.